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- Title
Different prognostic outcomes in two cases of FDG-PET/CT-Positive and -negative cardiac angiosarcoma.
- Authors
Ryo Yamakuni; Shiro Ishii; Shoki Yamada; Junko Hara; Hiroki Suenaga; Shigeyasu Sugawara; Hirofumi Sekino; Takayoshi Yamaki; Keiichi Ishida; Yuko Hashimoto; Hiroshi Ito
- Abstract
Cardiac angiosarcoma is a rare malignant tumor with a poor prognosis, characterized by the high uptake of 18F-fluorodeoxyglucose (FDG). This case report presents two cases of cardiac angiosarcoma with a marked difference in FDG uptake and prognosis. Case Summary : Case 1 : A 40-year-old male presented with syncope. Ultrasound echocardiography demonstrated a cardiac tumor with a high uptake of 18F-FDG (maximum standardized uptake value=9.2). The patient underwent heart catheterization and tumor biopsy. The pathological result was high-grade angiosarcoma, and the MIB-1(Ki-67) proliferation index was approximately 20%. Systemic chemotherapy was administered ; however, the patient died 2 years and 5 months after disease onset. Case 2 : A 65-year-old female had a right atrial tumor incidentally diagnosed during routine ultrasound echocardiography. The tumor exhibited a low uptake of 18F-FDG (maximum standardized uptake value=1.8). Open heart surgery was performed, and the tumor was completely resected. Histological analysis revealed low-grade angiosarcoma, and the MIB-1(Ki-67) proliferation index was less than 5%. The patient was followed-up and had not relapsed 2 years after surgery. Conclusion : 18F-FDG uptake may reflect pathological tumor grade and prognosis in cardiac angiosarcoma.
- Subjects
CARDIAC arrest; ULTRASONIC imaging; ECHOCARDIOGRAPHY; CARDIAC catheterization; CANCER chemotherapy
- Publication
Fukushima Journal of Medical Science, 2023, Vol 69, Issue 1, p45
- ISSN
0016-2590
- Publication type
Article
- DOI
10.5387/fms.2022-13