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- Title
Inherited thrombophilia and reproductive disorders.
- Authors
Liatsikos, Spyros A.; Tsikouras, Panagiotis; Manav, Bachar; Csorba, Roland; von Tempelhoff, Georg Friedrich; Galazios, Georgios
- Abstract
Apart from its established role in the pathogenesis of venous thromboembolism (VTE), inherited thrombophilia has been proposed as a possible cause of pregnancy loss and vascular gestational complications. There is a lot of controversy in the literature on the relationship between inherited prothrombotic defects and these obstetric complications. This is a review of the literature on inherited thrombophilia and reproductive disorders. Factor V Leiden, prothrombin G20210A mutation, and protein S deficiency seem to be associated with late and recurrent early pregnancy loss, while their impact on other pregnancy complications is conflicting. No definite association has been established between protein C and antithrombin deficiency and adverse pregnancy outcome, primarily due to their low prevalence. Screening is suggested only for women with early recurrent loss or late pregnancy loss. Anticoagulant treatment during pregnancy should be considered for women with complications who were tested positive for thrombophilia.
- Subjects
ANTICOAGULANTS; PREGNANCY complication risk factors; BLOOD coagulation disorders; BLOOD coagulation factors; BLOOD protein disorders; BLOOD proteins; FIBRIN; GENETIC disorders; EVALUATION of medical care; GENETIC mutation; PROTHROMBIN; RECURRENT miscarriage; DISEASE complications; PREGNANCY
- Publication
Journal of the Turkish-German Gynecological Association, 2016, Vol 17, Issue 1, p45
- ISSN
1309-0399
- Publication type
Article
- DOI
10.5152/jtgga.2016.15212