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- Title
Human Intestinal B-Cell Blasts and Plasma Cells Express the Mucosal Homing Receptor Integrin α4β7.
- Authors
Farstad, I. N.; Halstensen, T. S.; Lazarovits, A. I.; Norstein, J.; Fausa, O.; Brandtzaeg, P.
- Abstract
Interactions between homing receptors on circulating leucocytes and endothelial addressins regulate tissue-specific cellular extravasation. Although integrin α4β7 appears to be the main receptor for gut-homing T lymphocytes, less is known about molecules mediating mucosal B cell homing. Expression of integrin α4β7 on B lymphocytes, B cell blasts, and plasma cells in human gut-associated lymphoid tissue (GALT; the Peyer's patches and appendix) and lamina propria was studied by multi-colour immunofluorescence applied on cryosections. Isolated mononuclear cells from the same tissue compartments were examined by flow cytometry and compared with peripheral blood B cells. Integrin α4β7 was expressed by IgA+ B cell blasts and plasma ceils (CD38high) in the lamina propria, B cell blasts in GALT, and sIgD+ B lymphocytes in peripheral blood. In contrast, GALT sIgD+ B lymphocytes were negative or only weakly positive for β4β7. These results suggested that B lymphocytes down-regulate α4β7 upon extravasation in GALT but up-regulate this integrin after antigen-priming. Thus, α4β7 may be a homing receptor also for B cell blasts extravasating in the gut lamina propria, where this integrin is maintained on plasma cells, perhaps as a local retention factor.
- Subjects
GENE expression; INTEGRINS; B cells; LYMPHOCYTES; CELL receptors; LEUCOCYTES; T cells; PLASMA cells
- Publication
Scandinavian Journal of Immunology, 1995, Vol 42, Issue 6, p662
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1995.tb03709.x