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- Title
Effect of Cyclosporin A on the Generation of Cytotoxic T Lymphocytes in Mouse Mixed Lymphocyte Culture.
- Authors
Nemlander, A.; Häyry, P.
- Abstract
Cyclosporin A inhibited al equal concentrations both the proliferative response and the generation of cytotoxic T lymphocytes in one-way mouse spleen cell mixed lymphocyte culture. The50% inhibitory concentration was in all experiments 10-2 - to 10-1 μg ml. The inhibition was directly proportional lo how early the drug was added lo the culture: a complete inhibition of both responses was obtained if the drug was added on day 3, and a partial inhibition if added on day 4 of culture. Cytological analysis of the cultured cells demonstrated that resting lymphocytes were not damaged at 100-1000-fold concentrations of the drug giving complete inhibition of the blastogenic response. The results suggest that cyclosporin A is most effective if present throughout the induction phase of the immune response.
- Subjects
CYCLOSPORINE; LEUCOCYTES; LYMPHOID tissue; IMMUNOLOGY; ANTINEOPLASTIC antibiotics; CELL culture
- Publication
Scandinavian Journal of Immunology, 1980, Vol 12, Issue 6, p493
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1980.tb00096.x