We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Presence of monoclonal free light chains in the serum predicts risk of progression in monoclonal gammopathy of undetermined significance.
- Authors
Rajkumar, S. Vincent; Kyle, Robert A.; Therneau, Terry M.; Clark, Raynell J.; Bradwell, Arthur R.; Melton, L. Joseph; Larson, Dirk R.; Plevak, Matthew F.; Katzmann, Jerry A.
- Abstract
We hypothesized that the presence of monoclonal free light chains (FLC) in the serum of patients with monoclonal gammopathy of undetermined significance (MGUS) is a marker of clonal evolution and a risk factor for progression. Forty-seven patients with MGUS and documented progression to myeloma or related malignancy were compared with 50 age- and gender-matched patients with MGUS and no evidence of progression after 5 or more years of follow-up. The presence of an abnormal kappa/lambda FLC ratio in the serum was associated with a higher risk of MGUS progression (relative risk 2·5; 95% confidence interval: 1·6–4·0;P < 0·001).
- Subjects
BLOOD plasma; STATISTICAL hypothesis testing; HEMOLYSIS &; hemolysins; SERUM; BLOOD proteins; IMMUNE serums
- Publication
British Journal of Haematology, 2004, Vol 127, Issue 3, p308
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2004.05169.x