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- Title
short report T cell recognition of bcr/abl in healthy donors and in patients with chronic myeloid leukaemia.
- Authors
Westermann, Jörg; Schlimper, Claudia; Richter, Günther; Mohm, Johannes; Dörken, Bernd; Pezzutto, Antonio
- Abstract
In chronic myeloid leukaemia (CML), peptides from the fusion region of bcr3/abl2 are likely to play a role in anti-leukaemic T cell immunity. We investigated whether T cells that recognize bcr/abl fusion peptides could be detected in healthy donors and CML patients. T cell responses against bcr3/abl2 fusion peptides were analysed by γ-interferon enzyme-linked immunospot assays after prestimulation of peripheral blood mononuclear cells in the presence of anti-CD3-antibodies and interleukin-2. Our results suggest that the T cell repertoire contains bcr3/abl2-reactive T cells in CML patients who are in cytogenetic remission, but also in some healthy individuals.
- Subjects
MYELOID leukemia; PROTEIN binding; ANTINEOPLASTIC agents; T cells; CARRIER proteins; INTERLEUKIN-2
- Publication
British Journal of Haematology, 2004, Vol 125, Issue 2, p213
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2004.04873.x