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- Title
Allogeneic peripheral stem cell transplantation in a case of hereditary sideroblastic anaemia.
- Authors
González, M. I.; Caballero, D.; Vázquez, L.; Cañizo, C.; Hernández, R.; López, C.; Izarra, A.; Arroyo, J. L.; González, M.; García, R.; San Miguel, J. F.
- Abstract
We report on a case of pyridoxine refractory hereditary sideroblastic anaemia (HSA) in a 19-year-old man who underwent peripheral blood stem cell transplantation (PBSCT) from his HLA-identical brother. By using short tandem repeat polymorphism, 100% donor cells were observed in peripheral blood on day +21; bone marrow showed mixed chimaerism from day +21 to day +221, when 100% cells of donor origin were observed. The patient developed extensive chronic graft-versus-host disease with favourable response to treatment. When the haemoglobin range was normal, a programme of phlebotomies reduced serum ferritin levels. Three years after transplantation, the patient has an ECOG rating of 0, with completely normal haemoglobin values (15 g/dl). To our knowledge, this is the first PBSCT reported in a case of hereditary sideroblastic anaemia.
- Subjects
ANEMIA; STEM cell transplantation
- Publication
British Journal of Haematology, 2000, Vol 109, Issue 3, p658
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2000.02050.x