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- Title
HBV A<sub>1762</sub>T, G<sub>1764</sub>A Mutations Are a Valuable Biomarker for Identifying a Subset of Male HBsAg Carriers at Extremely High Risk of Hepatocellular Carcinoma: A Prospective Study.
- Authors
Fang, Zhong-Liao; Sabin, Caroline A.; Dong, Bai-Qing; Ge, Lian-Ying; Wei, Shao-Chao; Chen, Qin-Yan; Fang, Kong-Xiong; Yang, Jin-Ye; Wang, Xue-Yan; Harrison, Tim J.
- Abstract
OBJECTIVES: Surveillance of hepatocellular carcinoma (HCC) can detect small tumors for resection but at a huge cost of health resources. The challenge is to reduce the surveillance population. We reported that 96% of HCC patients but only 24% of controls were infected with the hepatitis B virus (HBV) with A1762T, G1764A mutations in Guangxi, China. It is likely to be extremely beneficial in terms of cost and resources if a significant number of tumors can be detected early by screening this selected population. Our aim is to test this hypothesis. METHODS: A cohort of 2,258 hepatitis B surface antigen-positive subjects aged 30–55 yr was recruited in Guangxi. Following evaluation of virological parameters at baseline, HCC is diagnosed by 6-monthly measurements of serum alpha-fetoprotein levels and ultrasonographic examinations. RESULTS: Sixty-one cases of HCC were diagnosed after 36 months of follow-up. The HCC rate was higher in the mutant than wild-type group ( P < 0.001, rate ratio [RR] 6.23, 95% confidence interval [CI] 2.83–13.68). The HCC rate in the male mutant group was higher than that in the male wild-type group ( P < 0.001, RR 11.54, 95% CI 3.58–37.24). Specifically, 93.3% of male cases are infected with the mutant. Multivariate analyses showed that in men, increasing age and A1762T, G1764A double mutations are independently associated with developing HCC. CONCLUSIONS: HBV A1762T, G1764A mutations constitute a valuable biomarker to identify a subset of male HBsAg carriers aged >30 yr at extremely high risk of HCC in Guangxi, and likely elsewhere.
- Subjects
GUANGXI Zhuangzu Zizhiqu (China); CHINA; HEPATITIS B virus; GASTROENTEROLOGY; LIVER cancer
- Publication
American Journal of Gastroenterology (Springer Nature), 2008, Vol 103, Issue 9, p2254
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1111/j.1572-0241.2008.01974.x