We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Glomerular endothelial cytotoxity and dysfunction in nephrosis with focal segmental glomerulosclerosis.
- Authors
Narisa Futrakul, Bob; Prasong Siriviriyakul, Bob; Tasanee Panichakul, Bob; Punnee Butthep, Bob; Suthiluk Patumraj, Bob; Prasit Futrakul, Bob
- Abstract
Glomerular endothelial cell dysfunction (GED) with defective release of vasodilator has been delineated in nephrosis (NS) in vivo and in vitro studies. In NS with focal segmental glomerulosclerosis (FSGS), an immunocirculatory balance may be impaired due to defective anti‐inflammatory cytokine. This study aimed at simultaneous determination of both proinflammatory cytokine (tumor necrosis factor alpha) and an anti‐inflammatory cytokine (interleukin‐10) in NS with FSGS. An endothelial cell cytotoxicity (ECC) was also examined using nephrotic serum. It was shown that (1) the initial endothelial cell cytotoxicity was significantly different from the control, (2) ratio between tumor necrosis alpha and interleukin‐10 was significantly elevated, and (3) intrarenal hemodynamics was changed significantly.
- Subjects
KIDNEY diseases; KIDNEY glomerulus; ANTI-inflammatory agents; TUMOR necrosis factors; CYTOKINES; HEMODYNAMICS
- Publication
Clinical Hemorheology & Microcirculation, 2003, Vol 29, Issue 3-4, p469
- ISSN
1386-0291
- Publication type
Article