We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Antenatal Depression and Risk of Gestational Diabetes, Adverse Pregnancy Outcomes, and Postpartum Quality of Life.
- Authors
Minschart, Caro; De Weerdt, Kyara; Elegeert, Astrid; Van Crombrugge, Paul; Moyson, Carolien; Verhaeghe, Johan; Vandeginste, Sofie; Verlaenen, Hilde; Vercammen, Chris; Maes, Toon; Dufraimont, Els; De Block, Christophe; Jacquemyn, Yves; Mekahli, Farah; De Clippel, Katrien; Van Den Bruel, Annick; Loccufier, Anne; Laenen, Annouschka; Devlieger, Roland; Mathieu, Chantal
- Abstract
<bold>Aims: </bold>To determine the impact of depressive symptoms on pregnancy outcomes and postpartum quality of life in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT).<bold>Methods: </bold>1843 women from a prospective cohort study received universal GDM screening with an oral glucose tolerance test (OGTT). The Center for Epidemiologic Studies-Depression questionnaire was completed before GDM diagnosis was communicated and in GDM women in early postpartum. All participants completed the 36-Item Short Form Health Survey (SF-36) health survey postpartum.<bold>Results: </bold>Women who developed GDM (231; 12.5%) had significantly more often depressive symptoms than NGT (1612; 87.5%) women [21.3% (48) vs 15.1% (239), odds ratio (OR) 1.52, 95% confidence interval (CI) (1.08-2.16), P = 0.017]. Compared to GDM women without depressive symptoms, depressed GDM women attended less often the postpartum OGTT [68.7% (33) vs 87.6% (155), P = 0.002], remained more often depressed [37.1% (13) vs 12.4% (19), P < 0.001], and had lower SF-36 scores postpartum. There were no significant differences in pregnancy outcomes between both groups. Rates of labor inductions were significantly higher in the NGT group with depressive symptoms compared to the nondepressed NGT group [31.7% (75) vs 24.7% (330), adjusted OR (aOR) 1.40, 95% CI (1.01-1.93), P = 0.041]. NGT women with depressive symptoms had lower SF-36 scores (P < 0.001) postpartum compared to nondepressed NGT women.<bold>Conclusions: </bold>Women with antenatal symptoms of depression develop more often GDM. GDM women with depressive symptoms remain more often depressed postpartum with lower quality of life. NGT women with depressive symptoms have higher rates of labor inductions and lower quality of life postpartum compared to nondepressed NGT women.
- Subjects
PREGNANCY outcomes; PUERPERIUM; QUALITY of life; GESTATIONAL diabetes; MENTAL depression; MENTAL health; RELATIVE medical risk; RESEARCH; RESEARCH methodology; BLOOD sugar; MEDICAL cooperation; EVALUATION research; HEALTH surveys; COMPARATIVE studies; PREGNANCY complications; DISEASE prevalence; RESEARCH funding; QUESTIONNAIRES; GLUCOSE tolerance tests; LONGITUDINAL method
- Publication
Journal of Clinical Endocrinology & Metabolism, 2021, Vol 106, Issue 8, pe3110
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgab156