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- Title
Transoral Laser Microsurgery of Recurrent Early Glottic Cancer After Radiation Therapy: Clinical Feasibility and Limitations.
- Authors
Jin Han, Young; Shin Lee, Hyoung; Won Kim, Sung; Chul Hong, Jong; Tae Kim, Seung; Sang Park, Hyo; Dae Lee, Kang
- Abstract
Objectives: Transoral laser microsurgery (TLM) is an accepted alternative to open partial laryngectomy for selected glottic cancers, but its role in salvage of radiation failure is debated. Methods: The records of 18 patients treated by TLM for rTl and rT2 glottic cancer after curative radiation therapy from 2002 to 2007 were retrospectively analyzed. Results: Of the 18 patients, 10 (56%) remained free of disease after the first TLM. The 5-year local control and laryngeal preservation rates showed better outcomes in rpTl tumors than in rpT2 tumors (87.5% versus 16.6%, p = 0.02; and 87.5% versus 33.3%, p = 0.03, respectively). However, the 5-year overall survival and disease-specific survival rates showed no significant difference between rpTl and rpT2 tumors. Conclusions: TLM can be a relatively safe and effective salvage option for rTl glottic cancer. However, because of its high local recurrence rate, TLM may not be generally recommended for rT2 glottic cancer.
- Subjects
MEDICAL lasers; RADIOTHERAPY; FROZEN tissue sections; GLOTTIS; LARYNGEAL tumors; METASTASIS; SURVIVAL analysis (Biometry); TUMOR classification; DISEASE relapse; LITERATURE reviews; TREATMENT effectiveness; RETROSPECTIVE studies; SALVAGE therapy; DATA analysis software; DESCRIPTIVE statistics; KAPLAN-Meier estimator; EVALUATION
- Publication
Annals of Otology, Rhinology & Laryngology, 2012, Vol 121, Issue 6, p375
- ISSN
0003-4894
- Publication type
Article
- DOI
10.1177/000348941212100603