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- Title
Signaling and regulation of G protein-coupled receptors in airway smooth muscle.
- Authors
Billington, Charlotte K.; Penn, Raymond B.
- Abstract
Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that have been identified in ASM cells, and discuss the extent to which signaling via these GPCRs has been characterized and linked to distinct ASM functions. In addition, we examine the role of GPCR signaling and its regulation in asthma and asthma treatment, and suggest an integrative model whereby an imbalance of GPCR-derived signals in ASM cells contributes to the asthmatic state.
- Subjects
G proteins; ASTHMA; OBSTRUCTIVE lung diseases; SMOOTH muscle; RESPIRATORY allergy; ADRENERGIC beta agonists; THERAPEUTIC use of glucocorticoids; DRUG therapy for asthma; ANIMAL experimentation; BRONCHIAL diseases; CELL receptors; CELLULAR signal transduction; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESPIRATORY organs; EVALUATION research; THERAPEUTICS
- Publication
Respiratory Research, 2003, Vol 4, p2
- ISSN
1465-9921
- Publication type
journal article
- DOI
10.1186/rr195