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- Title
Late viral or bacterial respiratory infections in lung transplanted patients: impact on respiratory function.
- Authors
Dubert, Marie; Visseaux, Benoit; Birgy, André; Mordant, Pierre; Metivier, Anne-Cécile; Dauriat, Gaelle; Fidouh, Nadhira; Yazdanpanah, Yazdan; Grall, Nathalie; Castier, Yves; Mal, Hervé; Thabut, Gabriel; Lescure, François-Xavier
- Abstract
<bold>Background: </bold>Respiratory infections are a major threat for lung recipients. We aimed to compare with a monocentric study the impact of late viral and bacterial respiratory infections on the graft function.<bold>Methods: </bold>Patients, who survived 6 months or more following lung transplantation that took place between 2009 and 2014, were classified into three groups: a viral infection group (VIG) (without any respiratory bacteria), a bacterial infection group (BIG) (with or without any respiratory viruses), and a control group (CG) (no documented infection). Chronic lung allograft dysfunction (CLAD) and acute rejection were analysed 6 months after the inclusion in the study.<bold>Results: </bold>Among 99 included lung recipients, 57 (58%) had at least one positive virological respiratory sample during the study period. Patients were classified as follows: 38 in the VIG, 25 in the BIG (among which 19 co-infections with a virus) and 36 in the CG. The BIG presented a higher initial deterioration in lung function (p = 0.05) than the VIG. But 6 months after the infection, only the VIG presented a median decrease of forced expiratory volume in 1 s; - 35 mL (IQR; - 340; + 80) in the VIG, + 140 mL (+ 60;+ 330) in the BIG and + 10 (- 84;+ 160) in the CG, p < 0.01. Acute rejection was more frequent in the VIG (n = 12 (32%)), than the BIG (n = 6 (24%)) and CG (n = 3 (8%)), p < 0.05, despite presenting no more CLAD (p = 0.21).<bold>Conclusions: </bold>Despite a less severe initial presentation, single viral respiratory infections seem to lead to a greater deterioration in lung function, and to more acute rejection, than bacterial infections.
- Subjects
RESPIRATORY infections; BACTERIAL diseases; LUNG infections; LUNG transplantation; VIRUS diseases; HUMAN metapneumovirus infection; BK virus
- Publication
BMC Infectious Diseases, 2020, Vol 20, Issue 1, p1
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-020-4877-3