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- Title
(279) THE ROLE OF TESTOSTERONE TREATMENT IN PATIENTS WITH METABOLIC SYNDROME: RESULTS FROM A META-ANALYSIS STUDY.
- Authors
Dr. Walter, Vena; Dr. Nicola, Bianchi; Dr. Francesca, Frizza; Dr. Francesca, Briganti; Prof. Giulia, Rastrelli; Prof. Linda, Vignozzi; Prof. Arcangelo, Barbonetti; Dr. Alessandro, Pizzocaro; Dr. Alessandro, Brunetti; Prof. Edoardo, Mannucci; Dr. Alessandra, Sforza; Prof. Mario, Maggi; Dr. Giovanni, Corona
- Abstract
Objectives: Metabolic syndrome (MetS) is often associated with male hypogonadism. Despite the well-known link, the role of testosterone [T] replacement therapy [TRT] on glycometabolic profile and body composition, in patients with metabolic syndrome [MetS], is still conflicting and argue of large scientific debate. The aim of the present study is to meta-analyze the role of TRT in MetS considering all placebo and non-placebo-controlled randomized clinical trials [RCTs]. Methods: An extensive Medline search was performed including the following words "testosterone", "metabolic syndrome" and "males". No search software was used, but we hand-searched bibliographies of retrieved papers for additional references. Results: Overall, 7 studies were available including 576 patients with a mean follow-up of 48.9 weeks. These trials differ in basal TT levels and type of T preparation used. In addition, only 6 were placebo controlled. TRT resulted to significantly improve waist circumferece, fasting glycemia, A1c serum levels, HOMA-Indes and serum tryglycerides (p < 0.001) when all studies were considered, however this difference was not significant when only placebo-controlled studies were considered, except for waist circumference (p= 0.05). When only placebo/controlled RCT were considered, TRT resulted to significantly improve body fat mass (p= 0.04). Conclusions: TRT was able to significantly decrease fasting glycaemia, glycosylated hemoglobin, HOMA-IR index, triglyceride levels, fat mass and waist circumference. In contrast, we did not observe any significant effect on total or HDL cholesterol, blood pressure and BMI. When considering only placebo-controlled studies, only differences of HbA1c, HOMA-IR index, triglyceride levels, fat mass and waist circumference retained statistical significance, but not fasting glycaemia, although a trend was apparent. Conflicts of Interest: No conflict of interest to declare.
- Subjects
METABOLIC syndrome; ADIPOSE tissues; WAIST circumference; BODY composition; GLYCOSYLATED hemoglobin; HYPERGLYCEMIA; MALE infertility
- Publication
Journal of Sexual Medicine, 2023, Vol 20, p1
- ISSN
1743-6095
- Publication type
Article
- DOI
10.1093/jsxmed/qdad062.153