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- Title
Clinical outcomes of intraductal carcinoma or cribriform in radical prostatectomy specimens of men opting for active surveillance: data from the PRIAS–JAPAN study.
- Authors
Tohi, Yoichiro; Ishikawa, Ryou; Kato, Takuma; Miyakawa, Jimpei; Matsumoto, Ryuji; Mori, Keiichiro; Mitsuzuka, Koji; Inokuchi, Junichi; Matsumura, Masafumi; Shiga, Kenichiro; Naito, Hirohito; Kohjimoto, Yasuo; Kawamura, Norihiko; Inoue, Masaharu; Kinoshita, Hidefumi; Hashimoto, Kohei; Goto, Keisuke; Haba, Reiji; Kakehi, Yoshiyuki; Sugimoto, Mikio
- Abstract
Background: Among early stage prostate cancer patients, intraductal carcinoma of the prostate (IDC-P) and invasive cribriform are key prognostic factors; however, their presence and clinical significance following active surveillance (AS) are unknown. In men who opted for AS, we aimed to examine the presence and impact of IDC-P or cribriform, utilizing radical prostatectomy (RP) specimens. Methods: We re-reviewed 137 RP specimens available in the PRIAS–JAPAN prospective cohort between January 2010 and September 2020. We assessed the presence of IDC-P or cribriform, and compared the patients' characteristics and prostate-specific antigen (PSA) recurrence-free survival after RP between groups with and without IDC-P or cribriform. In addition, we examined the predictive factors associated with IDC-P or cribriform. Results: The percentage of patients with IDC-P or cribriform presence was 34.3% (47 patients). IDC-P or cribriform pattern was more abundant in the higher Gleason grade group in RP specimens (P < 0.001). The rates of PSA recurrence-free survival were significantly lower in the IDC-P or cribriform groups than in those without them (log rank P = 0.0211). There was no association between IDC-P or cribriform on RP with the Prostate Imaging-Reporting and Data System (PI-RADS) 4,5 score on magnetic resonance imaging (MRI) before RP even with adjustments for other covariates (OR, 1.43; 95% confidence interval [CI] 0.511–3.980, P = 0.497). Conclusions: IDC-P or cribriform comprised approximately one-third of all RP specimens in men who underwent RP following AS, confirming their prognostic significance.
- Subjects
WATCHFUL waiting; RADICAL prostatectomy; MAGNETIC resonance imaging; PROSTATE cancer patients; PROSTATE-specific antigen
- Publication
International Journal of Clinical Oncology, 2023, Vol 28, Issue 2, p299
- ISSN
1341-9625
- Publication type
Article
- DOI
10.1007/s10147-022-02277-8