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- Title
Combination therapy with sorafenib and S-1 for renal cell carcinoma producing granulocyte colony-stimulating factor.
- Authors
Kyono, Yoko; Takayama, Tatsuya; Kinoshita, Mana; Kurita, Yutaka; Mugiya, Soichi; Baba, Satoshi; Ozono, Seiichiro
- Abstract
We present the first case report of the use of sorafenib and S-1 for the treatment of renal cell carcinoma (RCC) producing granulocyte colony-stimulating factor (G-CSF). This entity is clinically rare and has a poor outcome. A 78-year-old Japanese man presented with macrohematuria, left flank pain, and a palpable mass. Laboratory data showed marked leukocytosis with increased serum and urinary G-CSF. The histopathological diagnosis was unclassified RCC. New combination therapy with sorafenib and S-1 exerted a therapeutic effect and apparently decreased serum and urinary G-CSF levels, although the patient died of gastrointestinal perforation. The use of combined sorafenib and S-1 may be worthy of consideration in the treatment of RCC producing G-CSF.
- Subjects
JAPAN; ANTINEOPLASTIC agents; CANCER treatment; RENAL cell carcinoma; GRANULOCYTE-colony stimulating factor; HEALTH outcome assessment; OLDER men; LEUCOCYTOSIS; HISTOPATHOLOGY; DISEASES in older people
- Publication
International Journal of Clinical Oncology, 2011, Vol 16, Issue 3, p275
- ISSN
1341-9625
- Publication type
Article
- DOI
10.1007/s10147-010-0126-x