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- Title
Morphology of intraductal papillary neoplasm of the bile ducts: radiologic-pathologic correlation.
- Authors
Kim, Heejung; Lim, Jae; Jang, Kee; Kim, Min; Lee, Jongmee; Lee, Ji; Choi, Dongil; Lim, Hyo; Choi, Dong; Lee, Jong; Baron, Richard; Lim, Jae Hoon; Jang, Kee Taek; Kim, Min Ju; Lee, Ji Young; Lim, Hyo Keun; Choi, Dong Wook; Lee, Jong Kyun
- Abstract
<bold>Purpose: </bold>Intraductal papillary neoplasm of the bile duct (IPN-B) is known as a premalignant lesion of invasive cholangiocarcinoma. The purpose of this study was for radiologic-pathologic correlation of morphologic features of IPN-B and to correlate the subclassifications with biological behavior in regard to the bile duct wall invasion. <bold>Materials and Methods: </bold>A pathologist classified gross morphology of 75 cases (44 men and 31 women, age range, 39-85) of histopathologically proven IPN-B into polypoid, cast-like, superficial-spreading, and cyst-forming type. Preoperative images were retrospectively reviewed by two observers independently and classified the gross appearance of intraductal tumors into the four types. <bold>Results: </bold>The pathologist classified macroscopic appearances of 75 cases of IPN-B into polypoid type in 26, cast-like intraductal growth in 17, superficial-spreading growth in 21, and cyst-forming type in 11. Two observers classified image findings in accordance with pathologist's classification in 58 and 57 (77% and 76%) among the 75 cases of IPN-B, respectively; 18 and 19 of 26 cases of polypoid type, 14 and 14 of 17 cases of cast-like growth type, 16 and 19 of 21 cases of superficial-spreading type, 10 and 5 of 11 cases of cyst-forming type, respectively. Interobserver agreement for subclassification of tumor morphology was in the category of good agreement (k = 0.651). There was no correlation between morphological subclassification and tendency to invasive cholangiocarcinoma. <bold>Conclusion: </bold>IPN-Bs can be classified morphologically into polypoid, cast-like growth, superficial-spreading, and cystic type, but there is no correlation between the types and tendency to invasive cholangiocarcinoma.
- Subjects
MORPHOLOGY; DUCTAL carcinoma; PAPILLARY carcinoma; BILE duct tumors; MEDICAL radiology; PRECANCEROUS conditions; TOMOGRAPHY; HISTOPATHOLOGY
- Publication
Abdominal Imaging, 2011, Vol 36, Issue 4, p438
- ISSN
0942-8925
- Publication type
journal article
- DOI
10.1007/s00261-010-9636-2