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- Title
Morphological features of macular telangiectasia type 2 in Japanese patients.
- Authors
Shinkai, Akihiro; Saito, Wataru; Hashimoto, Yuki; Saito, Michiyuki; Kase, Satoru; Noda, Kousuke; Ishida, Susumu
- Abstract
Purpose: This study aimed to demonstrate the clinical course of Japanese patients with macular telangiectasia type 2 (MacTel-2). Methods: This retrospective observational case series included 16 eyes of 8 Japanese patients (3 men and 5 women) with MacTel-2. The mean age and follow-up duration was 66.9 years and 42.8 months, respectively. Differences in best-corrected visual acuity (BCVA), funduscopic macular findings, central macular thickness (CMT), and the length of macular ellipsoid zone (EZ) loss were compared between the initial/baseline and final visits. Optical coherence tomographic changes in CMT by ≥ 20% and in EZ loss by ≥ 20% or ≥ 100 μm were defined as improved or worsened. Results: Numerical changes in BCVA and EZ loss during follow-up were not statistically significant. However, the mean CMT at baseline, which was lower than that of healthy control eyes (P < 0.001), significantly increased during follow-up (P = 0.041). A certain proportion of eyes showed improvement in several parameters: funduscopic findings (both parafoveal retinal graying and foveal retinal pigment epithelium depigmentation) in 29% of eyes, CMT in 21% of eyes, and EZ loss in 43% of eyes. Conclusions: The non-negligible proportion of eyes with improved parameters, marked especially by macular EZ loss, suggests that Japanese patients with MacTel-2 have milder clinical features than Caucasian patients reported in the literature.
- Subjects
JAPANESE people; TELANGIECTASIA; RHODOPSIN; COHERENCE (Optics); VISUAL acuity
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2021, Vol 259, Issue 5, p1179
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-020-04989-x