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- Title
MR imaging-guided radiofrequency thermal ablation in the porcine brain at 0.2 T.
- Authors
Merkle, Elmar M.; Shonk, Jason R.; Zheng, Lan.; Duerk, Jeffrey L.; Lewin, Jonathan S.; Merkle, E M; Shonk, J R; Zheng, L; Duerk, J L; Lewin, J S
- Abstract
The aim of this study was to test the hypotheses that (a) MR imaging-guided radiofrequency (RF) thermal ablation is safe and feasible in porcine brain using an open C-arm-shaped low-field MR system, and that (b) induced thermal lesion size can be predicted using low-field MR imaging. Magnetic resonance-guided RF ablation was performed in the cerebral frontal lobes of six pigs. An 18-G monopolar RF electrode was inserted into the porcine brain using MR image guidance and RF was then applied for 10 min. After post-procedure imaging (T2-weighted, T1-weighted before and after gadodiamide administration), the pigs were killed and the brains were used for pathologic examination. Successful RF electrode placement was accomplished in all cases without complications; total magnet time ranged from 73 to 189 min. The thermal lesion size varied from 10 to 12 mm perpendicular to the electrode track and was easily visualized on T2-weighted and enhanced T1-weighted images. Enhanced T1-weighted imaging demonstrated the highest brain-to-RF thermal lesion contrast-to-noise ratio with an average of 1.5 +/- 1.6. Enhanced T1-weighted imaging never underestimated pathologic lesion diameter with a mean difference of 2.3 +/- 1.0 mm and a radiologic/pathologic correlation of 0.69. Magnetic resonance imaging-guided RF thermal ablation is feasible and safe in the porcine brain using an open MR low-field system. Induced-thermal lesion size can best be monitored using enhanced T1-weighted images. In the future, RF ablation under low-field MR guidance may offer an alternative treatment option for primary and secondary brain tumors.
- Subjects
MAGNETIC resonance imaging; RADIO frequency; ABLATION techniques; PORCINE somatotropin; SOMATOTROPIN; SWINE growth
- Publication
European Radiology, 2001, Vol 11, Issue 5, p884
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s003300000626