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- Title
Phloridzin-sensitive transport of echinacoside and acteoside and altered intestinal absorption route after application of C istanche tubulosa extract.
- Authors
Tanino, Tadatoshi; Nagai, Noriaki; Funakami, Yoshinori
- Abstract
Objectives The objective of this study was to address the beneficial effects of C istanche tubulosa extract on improving the low intestinal permeability of echinacoside ( ECH) and acteoside ( ACT). Methods Absorption of ECH and ACT in C . tubulosa extract was characterized using human intestinal Caco-2 cell monolayers with intact compounds. Glucose transporter-dependent absorption of ECH and ACT was confirmed by an in-situ intestinal perfusion technique. Key findings The apparent permeability ( Papp) was not significantly different between intact ECH and intact ACT. In the presence of phloridzin, the Papp of the ECH and ACT at a high dose was reduced to 20% of the respective non-treatment, but was not altered by phloretin and verapamil. C . tubulosa extract at low and high doses enhanced the Papp of ECH and ACT (both by threefold), resulting in their large participation in sodium-dependent glucose transporter-independent absorption. At a low concentration, concomitant ECH and ACT levels in portal blood were significantly suppressed by phloridzin. Conclusion The dietary and medicinal C . tubulosa extract enhancing the intestinal absorption of ECH and ACT may serve to better manage human health, although the involvement of phloridzin-sensitive transport should be reduced.
- Subjects
OROBANCHACEAE; INTESTINAL absorption; CAFFEIC acid derivatives; GLYCOSIDE derivatives; PHLORETIN; PLANT extracts; GLUCOSE transporters
- Publication
Journal of Pharmacy & Pharmacology, 2015, Vol 67, Issue 10, p1457
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1111/jphp.12450