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- Title
In vitro activity of tedizolid (TR-700) against linezolid-resistant staphylococci.
- Authors
Rodríguez-Avial, Iciar; Culebras, Esther; Betriu, Carmen; Morales, Gracia; Pena, Irene; Picazo, Juan J.
- Abstract
Objectives To compare the activity of tedizolid (formally known as torezolid and TR-700) with that of 15 agents against a collection of linezolid-resistant staphylococci (164 coagulase-negative staphylococci and 5 Staphylococcus aureus). Methods Antimicrobial susceptibility tests were performed using the broth microdilution method following the recommendations of the CLSI. Results All isolates were susceptible to vancomycin and tigecycline. Based on the MIC90 values, the potency of tedizolid against coagulase-negative staphylococci was >16-fold greater than that of linezolid. Tedizolid retained activity against most of the linezolid-resistant staphylococci tested, including multidrug-resistant isolates with elevated linezolid MICs (32 to >128 mg/L). Of the isolates, 79.2% and 31.4% were inhibited by tedizolid at ≤4 mg/L and ≤2 mg/L, respectively. Conclusions The results of this study confirm the activity of tedizolid against linezolid-resistant staphylococci. This new oxazolidinone could have an important role as a potential therapeutic agent against multidrug-resistant staphylococci.
- Subjects
STAPHYLOCOCCAL disease treatment; STAPHYLOCOCCUS aureus; MICROBIAL sensitivity tests; DRUG allergy; COAGULASE; THERAPEUTICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2012, Vol 67, Issue 1, p167
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkr403