We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Accumulation of five fluoroquinolones by Mycobacterium tuberculosis H37Rv.
- Authors
Piddock, Laura J. V.; Ricci, Vito; Piddock, L J; Ricci, V
- Abstract
The accumulation of ciprofloxacin, norfloxacin, moxifloxacin, levofloxacin and ofloxacin by Mycobacterium tuberculosis H37Rv was determined with a modified fluorescence method. The time to achieve a steady-state concentration (SSC) of each agent in M. tuberculosis was 60-240 s. Moxifloxacin was accumulated to the lowest concentration and ciprofloxacin to the highest. However, ciprofloxacin took longer to achieve an SSC than the other four agents; levofloxacin reached steady state in the shortest time. Larger fluoroquinolones accumulated to the lowest concentration and more slowly. Although all five agents had low hydrophobicity values (P(app) < or =0.11), those with the lowest values accumulated to the higher concentrations.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2001, Vol 48, Issue 6, p787
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/48.6.787