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- Title
Teicoplanin in the treatment of enterococcal endocarditis: clinical and microbiological study.
- Authors
Venditti, M; Tarasi, A; Capone, A; Galié, M; Menichetti, F; Martino, P; Serra, P; Galié, M
- Abstract
Seven cases of enterococcal endocarditis treated with teicoplanin (7-10 mg/kg/day for 28-105 days) alone (one case) or in combination with aminoglycosides (six cases) were reviewed. All patients were cured. Serum bactericidal activity titres after intravenous gentamicin (5 mg/kg every 24 h) and teicoplanin (10 mg/kg every 24 h) were measured on day 7 of treatment in four patients against five enterococcal isolates: mean titres were 1:54 (range 1:16-64) and 1:22 (1:8-32) at 0.5 and 24 h post-infusion, respectively. Time-kill studies showed synergy between teicoplanin and gentamicin against three isolates. We conclude that single daily-dose teicoplanin/gentamicin combined therapy may represent a rational alternative to standard penicillin/gentamicin therapy and a useful regimen for home treatment of selected cases of enterococcal endocarditis.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1997, Vol 40, Issue 3, p449
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/40.3.449