We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Neonatal diabetes: A case series.
- Authors
Ganesh, Ramaswamy; Suresh, Natarajan; Vasanthi, Thiruvengadam; Ravikumar, K.
- Abstract
Background: Neonatal diabetes mellitusis a rare disorder with an incidence of 1 in 2,60,000 live births. Methods: Retrospective analysis of clinical and genetic profile of children admitted with neonatal diabetes mellitus in a tertiary-care hospital in Chennai, India over 11 years. Results: Ten children were diagnosed with neonatal diabetes of whom 9 had permanent neonatal diabetes mellitus. The age range at onset was from 3 days- 5 months. Of the 9 children, KCNJ11 gene mutation was positive in one, and ABCC 8 and INS gene mutation in two children each. Children with KCNJ11 and ABCC 8 gene mutations were switched over to oral sulfonyl urea therapy. Conclusion: Few genotypes causing NDM can be managed effectively with oral sulfonyl ureas.
- Subjects
INDIA; DIAGNOSIS of diabetes; NEONATAL diseases; DRUG therapy; TERTIARY care; PUBLIC health; GENETICS
- Publication
Indian Pediatrics, 2017, Vol 54, Issue 1, p33
- ISSN
0019-6061
- Publication type
Article
- DOI
10.1007/s13312-017-0993-6