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- Title
Sequential use of letrozole and gonadotrophin in women with poor ovarian reserve: a randomized controlled trial.
- Authors
Lee, Vivian Chi Yan; Chan, Carina Chi Wai; Ng, Ernest Hung Yu; Yeung, William Shu Biu; Pak Chung Ho
- Abstract
Sequential use of letrozole and human menopausal gonadotrophin (HMG) was compared with HMG only in poor ovarian responders undergoing IVF. Patients (n = 53) with less than four oocytes retrieved in previous IVF cycles or less than five antral fob tides were randomized to either letrozole for 5 days followed by HMG or HMG atone. The letrozole group had lower dosage of HMG (P < 0.001), shorter duration of HMG (P < 0.001) and fewer oocytes (P = 0.001) when compared with controls. Live-birth rate was comparable with a tower miscarriage rate in the letrozole group (P = 0.038). Serum FSH concentrations were comparable in bot groups except on day 8, white oestradiol concentrations were all lower in the letrozole group from day 4 (all P < 0.001). Follicula fluid concentrations of testosterone, androstenedione, FSH and anti-Müllerian hormone were higher in the letrozole group (P = 0.009, P = 0.001, P = 0.046 and P = 0.034, respectively). Compared with HMG alone, sequential use of letrozole and HMG in poor responders resulted in significantly tower total dosage and shorter duration of HMG, a comparable live-birth rate, a significantly tower miscarriage rate and a more favourable hormonal environment of follicular fluid.
- Subjects
OVUM; GONADOTROPIN; LETROZOLE; CHILDBIRTH; MISCARRIAGE
- Publication
Reproductive BioMedicine Online (Reproductive Healthcare Limited), 2011, Vol 23, Issue 3, p380
- ISSN
1472-6483
- Publication type
Article
- DOI
10.1016/j.rbmo.2011.05.012