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- Title
Development of a nomogram based on markers of ovarian reserve for the individualisation of the follicle-stimulating hormone starting dose in in vitro fertilisation cycles.
- Authors
La Marca, A; Papaleo, E; Grisendi, V; Argento, C; Giulini, S; Volpe, A
- Abstract
Please cite this paper as: La Marca A, Papaleo E, Grisendi V, Argento C, Giulini S, Volpe A. Development of a nomogram based on markers of ovarian reserve for the individualisation of the follicle-stimulating hormone starting dose in in vitro fertilisation cycles. BJOG 2012;119:1171-1179. Objective To elaborate a nomogram based on markers of ovarian reserve for the calculation of the appropriate starting dose of follicle-stimulating hormone (FSH). Design Cohort study of infertile women. Setting In vitro fertilisation (IVF) unit, University Hospital of Modena, Italy. Population Women aged 18-40 years ( n = 346) and undergoing their first IVF cycle. Methods Serum FSH and anti-Müllerian hormone (AMH) measurement. Main outcome measures Development of a model for the prediction of ovarian response to FSH. Results A model based on age, AMH and FSH was able to accurately predict the ovarian sensitivity and accounted for 30% of the variability of ovarian response to FSH. An FSH dosage nomogram was constructed and overall it predicts a starting FSH dose <225 IU in 55.1 and 25.9% of women younger and older than 35 years, respectively. Conclusions In the present study we clearly demonstrated that the daily FSH dose may be calculated on the basis of a woman's age and two markers of ovarian reserve, namely AMH and FSH, with the first two vari;s (age and AMH) being the most significant predictors. The nomogram we developed seems easily applicable for clinicians during their daily clinical practice.
- Subjects
NOMOGRAPHY (Mathematics); FOLLICLE-stimulating hormone; HUMAN in vitro fertilization; FERTILIZATION in vitro; ANTI-Mullerian hormone; REPRODUCTIVE technology
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2012, Vol 119, Issue 10, p1171
- ISSN
1470-0328
- Publication type
Article
- DOI
10.1111/j.1471-0528.2012.03412.x