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- Title
Role of adjuvant radiotherapy in salivary gland cancers.
- Authors
Kordzińska-Cisek, Izabela; Grzybowska-Szatkowska, Ludmiła
- Abstract
Neoplasms of large salivary glands are a highly differentiated group of diseases in terms of their histology. There are 24 histological types of these tumors, the most common of which are mucoepidermoid carcinoma and adenoid cystic carcinoma. The mainstay of radical treatment is surgical removal of the salivary gland, which, in certain patients, is supplemented with radiation therapy or chemoradiotherapy. There are no large randomized prospective studies that would show an overall survival or local control benefit in individual types of this disease. Research demonstrates that salivary gland tumors are generally resistant to radiation. Despite this, adjuvant radiotherapy is applied in patients without radical surgical margins and with highly advanced disease in most of these histological types. However, scientific investigations do not confirm the influence of adjuvant treatment on LC and OS in the mucoepidermoid type. Nevertheless, this treatment increases local control and prolongs overall survival in patients with adenoid cystic carcinoma and adenocarcinoma. As for acinic cell carcinoma and malignant mixed tumor, the benefit from radiotherapy is unclear. Irradiation in these diseases may improve local control and prolong survival in more advanced cases. As in other head and neck cancers, radiation therapy and chemoradiotherapy should be applied in patients with squamous cell carcinoma of the salivary glands. Due to the rare occurrence of other histological types, data on the benefit from radiotherapy are lacking. Adjuvant radiotherapy has been shown to improve survival only in patients with more advanced basal cell carcinoma.
- Subjects
SALIVARY gland cancer; SALIVARY gland diseases; RADIOTHERAPY; HOSPITAL radiological services; TUMOR growth prevention; CANCER treatment; PHYSIOLOGY
- Publication
Onkologia i Radioterapia, 2017, Vol 40, Issue 2, p31
- ISSN
1896-8961
- Publication type
Article