We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Masked Hypertension, Endothelial Dysfunction, and Arterial Stiffness in Type 2 Diabetes Mellitus: A Pilot Study.
- Authors
Takeno, Kageumi; Mita, Tomoya; Nakayama, Shiho; Goto, Hiromasa; Komiya, Koji; Abe, Hiroko; Ikeda, Fuki; Shimizu, Tomoaki; Kanazawa, Akio; Hirose, Takahisa; Kawamori, Ryuzo; Watada, Hirotaka
- Abstract
BackgroundThe aim of this study was to assess the relationship between masked hypertension (MHT) and vascular damage in patients with type 2 diabetes.MethodsThe study subjects were patients with type 2 diabetes who were normotensive based on blood pressure (BP) measurement in the clinic (n = 80) without antihypertensive drugs and free of retinopathy, macroalbuminuria, overt cardiovascular disease. Subjects underwent 24-h ambulatory blood pressure monitoring (ABPM), measurement of flow-mediated dilatation (FMD), and brachial-ankle pulse wave velocity (baPWV). Based on the results of ABPM, subjects with mean daytime systolic BP ≥135 and/or 85 mm Hg were defined as MHT and their clinical data were compared with those of normotensive patients (NT). The data were also compared with those of type 2 diabetic patients with hypertension (HT) as measured in the clinic (n = 32).ResultsMHT was detected in 47.5% of the study subjects with normotension at clinic (n = 38). Impaired FMD (5.65 ± 2.00% for NT, 4.26 ± 1.88% for MHT, 3.90 ± 1.71% for HT, P < 0.001) and higher baPWV (1,514.2 ± 212.7 cm/s for NT, 1,749.9 ± 339.7 cm/s for MHT, and 1,768.6 ± 302.8 cm/s for HT, P < 0.001) were similarly noted in patients with MHT and HT compared with NT. Multivariate regression analysis indicated that daytime systolic BP measured by ABPM, the estimated duration of diabetes and serum triglycerides were significantly associated with FMD and daytime systolic BP measured by ABPM, not systolic BP at clinic, age, and HbA1c were significantly associated with baPWV.ConclusionsGiven that patients with impaired FMD and higher baPWV are known to be at higher risk of cardiovascular disease, our data suggest that type 2 diabetic patients with MHT could be also at increased risk of cardiovascular disease.American Journal of Hypertension (2012). doi:10.1038/ajh.2011.158
- Subjects
HYPERTENSION; CARDIOVASCULAR disease diagnosis; BLOOD pressure; DIAGNOSIS; CLINICAL medicine research; DIAGNOSIS of diabetes
- Publication
American Journal of Hypertension, 2012, Vol 25, Issue 2, p165
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1038/ajh.2011.158