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- Title
Common genetic basis of ALS patients and soccer players may contribute to disease risk.
- Authors
Ben-Zaken, Sigal; Nefussy, Beatrice; Meckel, Yoav; Eliakim, Alon; Nemet, Dan; Gotkine, Marc; Lorber, Dana; Zeev, Aviva; Drory, Vivian E.
- Abstract
Objective: The aim of the present study was to determine the prevalence of the ACSL A/G single nucleotide polymorphism among athletes and patients with amyotrophic lateral sclerosis (ALS). ALS is a progressive neurodegenerative disorder of motor neurons that leads to paralysis and death usually within 3–5 years from onset. Previous epidemiological studies reported a higher risk of ALS among soccer players. The ACSL (long-chain-fatty-acid-CoA ligase 1) gene codes the long-chain fatty-acid-coenzyme A ligase family that plays a key role in lipid biosynthesis and fatty acid oxidation. The ACSL A/G polymorphism is associated with endurance trainability. Methods: One hundred and seventy-eight ALS patients, 172 athletes (60 soccer players, 112 middle- and long-distance runners), and 111 nonathletic controls participated in the study. Genomic DNA was extracted from blood or buccal cells according to the salting-out procedure. Genotypes were determined using the TaqMan allelic discrimination assay. Results: The prevalence of the ACSL AA genotype was significantly higher among soccer players (35.0%) and ALS patients (39.3%) compared to runners (16.1%) and controls (18.0%). However, ALS GG carriers had a higher mortality rate. Conclusion: We postulate that soccer players and ALS patients carry a common genetic predisposition that is related to impaired fatty acid utilization. Moreover, while the A allele might be associated with a genetic predisposition toward ALS, especially among soccer players, the G allele might be associated with disease severity. Further research is needed in order to explore the role of the ACSL rs6552828 polymorphism in ALS.
- Subjects
SOCCER players; SINGLE nucleotide polymorphisms; AMYOTROPHIC lateral sclerosis; FATTY acid oxidation; LONG-distance runners
- Publication
Neurological Sciences, 2022, Vol 43, Issue 7, p4231
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-022-05990-4