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- Title
Incidental finding of maternal malignancy in an unusual non‐invasive prenatal test and a review of similar cases.
- Authors
Moellgaard, Maria Hammer; Lund, Ida Charlotte Bay; Becher, Naja; Skytte, Anne‐Bine; Andreasen, Lotte; Srebniak, Malgorzata Ilona; Vogel, Ida
- Abstract
We present a clinical case where a complex abnormal non‐invasive prenatal test (NIPT) result in a research project revealed carcinoma of the breast in the pregnant woman. Furthermore, the NIPT result did not demonstrate the same fetal chromosomal aberration as the chorion villus sample. A literature search for similar cases was performed identifying 43 unique cases, where abnormal NIPT results were related to maternal malignancy. Malignancy is a rare but important cause of complex abnormal non‐invasive prenatal test (NIPT) results and should be considered when fetal karyotype and abnormal NIPT results are discordant. Furthermore, a follow‐up invasive sample is essential for correct fetal diagnosis when abnormal NIPT results are found.
- Subjects
PRENATAL diagnosis; CHORIONIC villus sampling; CHROMOSOME abnormalities
- Publication
Clinical Case Reports, 2022, Vol 10, Issue 10, p1
- ISSN
2050-0904
- Publication type
Case Study
- DOI
10.1002/ccr3.6280