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- Title
Failure of Cilostazol in the Prevention of Ventricular Fibrillation in a Patient with Brugada Syndrome.
- Authors
ABUD, ATILIO; BAGATTIN, DANIEL; GOYENECHE, RAUL; BECKER, CARLOS
- Abstract
The ECG appearance in Brugada syndrome is caused by failure of the dome of the action potential to develop. Increased activity of the I(to) current in epicardial cells generates a transmural gradient with repolarization dispersion between the epicardium and the endocardium in the right ventricular wall, thus favoring the development of VF by a phase 2 reentry mechanism. The efficacy of cilostazol for the management of these arrhythmias has been reported. This drug is a phosphodiesterase inhibitor with positive chronotropic properties, thus blocking outward potassium currents I(to) in the myocardial tissue. We present a patient with Brugada syndrome with an implantable cardioverter defibrillator (ICD), who suffered multiple ICD discharges due to VF during therapy with this drug.
- Subjects
DRUG efficacy; PHARMACODYNAMICS; VENTRICULAR fibrillation; BRUGADA syndrome; ARRHYTHMIA; CARDIAC arrest; PREVENTION
- Publication
Journal of Cardiovascular Electrophysiology, 2006, Vol 17, Issue 2, p210
- ISSN
1045-3873
- Publication type
Article
- DOI
10.1111/j.1540-8167.2005.00290.x