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- Title
Association of adiponectin +276G/T polymorphism with knee osteoarthritis.
- Authors
DONG ZHAN; PONGSAK YUKTANANDANA; WILAI ANOMASIRI; AREE TANAVALEE; SITTISAK HONSAWEK
- Abstract
Osteoarthritis (OA) is a prevalent, degenerative joint disorder leading to the destruction of articular cartilage, osteophyte formation and subchondral bone sclerosis. Genetic and environmental factors are involved in the development of OA. The role of adiponectin gene polymorphisms in OA has not yet been established. The aim of this study was to investigate the association of adiponectin +276G/T (rs1501299) gene polymorphism with knee OA. Genotype distributions and allelic frequencies of adiponectin gene, +276G/T polymorphism were determined in a total of 200 subjects (100 knee OA patients and 100 healthy controls). Single-nucleotide polymorphism (SNP) of the adiponectin +276G/T gene was genotyped by polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis. The genotype distribution of +276G/T SNP was observed in the Hardy-Weinberg equilibrium for OA patients and controls. No statistically significant difference was identified between the two groups with respect to genotype distributions and allelic frequencies (P>0.05). The T- and G-allele frequencies were indicated as 24.5 and 75.5%, respectively, in OA patients, whereas the frequency was 23-70% in the control group. Findings of this study therefore suggest that the +276G/T SNP was not associated with susceptibility to knee OA.
- Subjects
OSTEOARTHRITIS; GENETIC polymorphism research; ADIPONECTIN; SINGLE nucleotide polymorphisms; KNEE diseases
- Publication
Biomedical Reports, 2014, Vol 2, Issue 2, p229
- ISSN
2049-9434
- Publication type
Article
- DOI
10.3892/br.2014.228