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- Title
Genetic variation in leptin and leptin receptor genes as a risk factor for idiopathic male infertility.
- Authors
Hodžić, A.; Ristanović, M.; Zorn, B.; Tulić, C.; Maver, A.; Novaković, I.; Plaseska‐Karanfilska, D.; Peterlin, B.
- Abstract
The aim of this study was to examine whether there is an association among genetic variability in leptin ( LEP) and leptin receptor ( LEPR) genes and male infertility. We performed a case-control study and were searching for an association between polymorphisms of LEP and LEPR genes and male infertility. The study group consisted of 317 patients with idiopathic infertility and a control group of 241 fertile men from Slovenia. Four single nucleotide polymorphisms ( SNPs) in LEP gene and four single nucleotide polymorphisms ( SNPs) in LEPR gene were chosen and genotyped. Statistically significant SNP was further validated in additional 255 infertile patients and 168 controls from Serbia and Macedonia. In the Slovenian population, we found a statistically significant difference in genotype distribution for rs10244329 polymorphism in LEP gene (recessive genotype model, p value = 0.048). The trend toward statistically significant difference in genotype distribution for rs10244329 polymorphism was confirmed in the Serbian and Macedonian populations ( p value = 0.07). Our data suggest that genetic variability in the LEP gene might be associated with male infertility warranting further confirmation and mechanistic investigations.
- Subjects
LEPTIN; LEPTIN receptors; INFERTILITY; SINGLE nucleotide polymorphisms; GENOTYPES; PHYSIOLOGY
- Publication
Andrology, 2017, Vol 5, Issue 1, p70
- ISSN
2047-2919
- Publication type
Article
- DOI
10.1111/andr.12295