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- Title
Current understanding of meningeal and cerebral vascular function underlying migraine headache.
- Authors
Levy, Dan; Labastida-Ramirez, Alejandro; MaassenVanDenBrink, Antoinette
- Abstract
<bold>Background: </bold>The exact mechanisms underlying the onset of a migraine attack are not completely understood. It is, however, now well accepted that the onset of the excruciating throbbing headache of migraine is mediated by the activation and increased mechanosensitivity (i.e. sensitization) of trigeminal nociceptive afferents that innervate the cranial meninges and their related large blood vessels.<bold>Objectives: </bold>To provide a critical summary of current understanding of the role that the cranial meninges, their associated vasculature, and immune cells play in meningeal nociception and the ensuing migraine headache.<bold>Methods: </bold>We discuss the anatomy of the cranial meninges, their associated vasculature, innervation and immune cell population. We then debate the meningeal neurogenic inflammation hypothesis of migraine and its putative contribution to migraine pain. Finally, we provide insights into potential sources of meningeal inflammation and nociception beyond neurogenic inflammation, and their potential contribution to migraine headache.
- Subjects
MIGRAINE; MENINGES; BLOOD vessels; CRITICAL currents; CELL populations
- Publication
Cephalalgia, 2019, Vol 39, Issue 13, p1606
- ISSN
0333-1024
- Publication type
journal article
- DOI
10.1177/0333102418771350