We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Real-World Experience with Coformulated Ledipasvir and Sofosbuvir for HIV-Positive Patients with HCV Genotype 2 Infection: A Multicenter, Retrospective Study.
- Authors
Liou, Bo-Huang; Sun, Hsin-Yun; Yang, Chia-Jui; Syue, Ling-Shan; Lee, Yu-Lin; Tang, Hung-Jen; Tsai, Hung-Chin; Lin, Chi-Ying; Chen, Tun-Chieh; Lee, Chun-Yuan; Huang, Sung-Hsi; Liu, Chia-Wei; Lu, Po-Liang; Lin, Shih-Ping; Wang, Ning-Chi; Cheng, Aristine; Ko, Wen-Chien; Cheng, Shu-Hsing; Hung, Chien-Ching
- Abstract
Introduction: While coformulated ledipasvir (90 mg)/sofosbuvir (400 mg) (LDV/SOF) is approved for the treatment of hepatitis C virus (HCV) genotype 2 (GT2) infection in Taiwan, Japan, and New Zealand, data regarding its use for HIV (Human Immunodeficiency Virus)-positive patients infected with HCV GT2 are sparse. We aimed to assess the effectiveness and tolerability of LDV/SOF for HIV-positive patients with HCV GT2 coinfection. Methods: From January 2019 to July 2020, consecutive HIV-positive Taiwanese patients infected with HCV GT2 who received LDV/SOF were retrospectively included for analysis. The effectiveness was determined by sustained virologic response 12 weeks off-therapy (SVR12). Results: Of the 114 patients (mean age, 38.6 years) initiating LDV/SOF during the study period, 0.9% had liver cirrhosis and 4.4% were HCV treatment-experienced. All patients had estimated glomerular filtration rate (eGFR) > 30 ml/min/1.73 m2 and were receiving antiretroviral therapy with 98.2% having CD4 counts ≥ 200 cells/mm3 and 93.9% plasma HIV RNA load < 50 copies/ml. Antiretrovirals prescribed included tenofovir alafenamide/emtricitabine in 42.1%, tenofovir disoproxil fumarate (TDF)/emtricitabine 18.4%, other nucleoside reverse transcriptase inhibitors (NRTIs) 39.5%, non-NRTIs 12.3%, protease inhibitors 13.2%, and integrase inhibitors 74.6%. All patients had undetectable plasma HCV RNA load at the end of treatment, and 96.5% achieved SVR12 in intention-to-treat analysis. The on-treatment eGFR decline was more pronounced in those receiving TDF-containing antiretroviral therapy (mean change, − 8.33 ml/min/1.73 m2), which was reversible after discontinuation of LDV/SOF. None of the patients interrupted LDV/SOF during the 12-week treatment course. Conclusion: Similar to the response observed among HIV-negative patients, LDV/SOF is effective for HIV-positive patients coinfected with HCV GT2.
- Subjects
TAIWAN; NEW Zealand; HIV-positive persons; NUCLEOSIDE reverse transcriptase inhibitors; SOFOSBUVIR; MIXED infections; HIV
- Publication
Infectious Diseases & Therapy, 2021, Vol 10, Issue 2, p827
- ISSN
2193-8229
- Publication type
Article
- DOI
10.1007/s40121-021-00424-8