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- Title
Grown-up coeliac children: the effects of only a few years on a gluten-free diet in childhood.
- Authors
Ciacci, C.; Iovino, P.; Amoruso, D.; Siniscalchi, M.; Tortora, R.; Di Gilio, A.; Fusco, M.; Mazzacca, G.
- Abstract
: To evaluate clinical and psychological status of adults with childhood diagnosis of coeliac disease who were re-exposed to gluten after only a few years and now on a gluten-containing diet, compared with adults with recent diagnosis of coeliac disease, and adults who remained on gluten-free diet after childhood diagnosis.: A total of 195 adults with a biopsy suggestive of coeliac disease in childhood, who either had adhered to a gluten-free diet for at least 1 year after diagnosis and now are either on gluten-free diet (n = 110) or on gluten-containing diet (n = 85), and adults with newly diagnosed coeliac disease (n = 165) underwent a medical check-up.: Body mass index and main laboratory indices were statistically different among groups (lowest in never on gluten-free diet, highest in gluten-free diet). The lowest average levels of bone mineral density were found among never on gluten-free diet patients. Prevalence of autoimmune disorders was increased in never on gluten-free diet when compared with the transient gluten-free diet and gluten-free diet groups. Histology revealed villous subatrophy in all patients of never on gluten-free diet group, in 39 of 110 patients of gluten-free diet and in 84 of 85 of transient gluten-free diet groups. Herpetiform dermatitis was found in three patients of gluten-free diet, three of transient gluten-free diet and three of never on gluten-free diet. Dental enamel defects were found in 15 patients of transient gluten-free diet, 43 of never on gluten-free diet and in zero of the gluten-free diet group. Pregnancy outcome was not significantly different between the two groups, but neonatal weight was lower and breast feeding was shorter in the never on gluten-free diet group. Sexual habits, alcohol intake and cigarette smoking were significantly different in the never on gluten-free diet group when compared with the other two groups.: Gluten withdrawal in childhood partly protects coeliac adults from clinical and behavioural effects of gluten sensitivity.
- Subjects
CELIAC disease in children; GLUTEN-free diet; DIET therapy for children; DIAGNOSIS; DIGESTIVE system diseases; MALABSORPTION syndromes; THERAPEUTICS; CLINICAL pharmacology
- Publication
Alimentary Pharmacology & Therapeutics, 2005, Vol 21, Issue 4, p421
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2005.02345.x