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- Title
Safety of vaccinating sibling donors with live-attenuated varicella zoster vaccine before hematopoietic stem cell transplantation.
- Authors
Leung, A. Y. H.; Chow, H. C. H.; Kwok, J. S. Y.; Lui, C. K. H.; Cheng, V. C. C.; Yuen, K.-Y.; Lie, A. K. W.; Liang, R.
- Abstract
Reactivation of varicella zoster virus (VZV), clinically manifested as herpes zoster (HZ) is a common complication after hematopoietic stem cell transplantation (HSCT). The optimum prophylaxis for this disease has not been defined. In this study, we examined the effects of vaccinating donors with a live-attenuated vaccine with particular reference to their immune responses and the outcome of HSCT patients. Forty prospective HLA-matched sibling donors were vaccinated before HSCT. There were humoral immune responses in both sero-positive (P<0.01) and sero-negative (P=0.058) donors. Cellular immune response was assayed in 26 donors. Significant correlation was observed between cellular immune responses as enumerated by thymidine incorporation and interferon γ secretion (P<0.001) and the latter was used in subsequent analyses. Significant response was observed in sero-negative (6/26) and a group of sero-positive (13/26) donors while 7/26 sero-positive donors showed no response. Thirty-four HSCT were performed. These patients have a lower, albeit insignificant, risk of HZ compared with historical controls and only 3/34 patients developed single dermatomal HZ at 6, 9 and 28 months after HSCT. No patients developed VZV-related mortality. Vaccinating donors with live-attenuated VZV vaccine was safe, but whether it confers a significant protection to the patients would require further study.Bone Marrow Transplantation (2007) 39, 661–665. doi:10.1038/sj.bmt.1705673; published online 9 April 2007
- Subjects
MEDICAL sciences; COMMUNICABLE diseases; HERPESVIRUS diseases; VARICELLA-zoster virus; TRANSPLANTATION of organs, tissues, etc.; PATIENTS; CHARITABLE uses, trusts, &; foundations; HEMATOPOIETIC stem cells
- Publication
Bone Marrow Transplantation, 2007, Vol 39, Issue 11, p661
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1705673