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- Title
Ethnic and gender differences in electrocardiographic QT length and QT dispersion in hypertensive subjects.
- Authors
Chapman, N; Mayet, J; Ozkor, M; Foale, R; Thom, S; Poulter, N
- Abstract
Background: Prolonged QT intervals and/or increased QT dispersion (QT[SUBd]) are associated with various pathological conditions and predict death in healthy individuals. Among hypertensives, (QT[SUBd] correlates with blood pressure (BP) and left ventricular mass index (LVMI) and QT intervals are prolonged in those with left ventricular hypertrophy (LVH). In normotensives, heart-rate corrected QT length (QT[SUBc]) is longer in females than males, but QT[SUBd] is greater in males than females. There are few data comparing QT parameters between different ethnic groups and none specifically in hypertensives. Among normotensives, compared with (whites, QT[SUBc] is reported to be shorter in African-Americans and longer in Chinese. We looked for ethnic and gender differences in QT parameters in hypertensive subjects. Methods: Untreated hypertensives were selected from a Hypertension Clinic database. Black and white subjects were matched for age, sex, BP and LVMI. Male and female subjects were matched for age, race, BP and the presence or absence of echocardiographic LVH. Maximum QT intervals (QT[SUBm]), rate-corrected maximum QT intervals (QT[SUBc]) and QT dispersion (QT[SUBd]) were measured or calculated from ECGs. Data are presented as mean ± s.d. Differences in QT parameters were sought between groups using Student's t-tests. Results: No ethnic or gender differences in QT parameters achieved statistical significance. However there was a tendency for (QT[SUBm] and (QT[SUBc] to be prolonged in blacks compared with whites (443 ± 52 vs 421 ± 47; P = 0.08 and 480 ± 65 vs 463 ± 40: P = 0.24 respectively), and for QTc to be prolonged in females compared with males (479 ± 52 vs 461 ± 45 ms; P = 0.13). Conclusion: In small groups of matched hypertensives, no ethnic or gender differences in QT parameters achieved statistical significance. However, similar to findings in normotensives, (QT[SUBc] tended to be longer in...
- Subjects
ETHNICITY; HEALTH
- Publication
Journal of Human Hypertension, 2000, Vol 14, Issue 6, p403
- ISSN
0950-9240
- Publication type
Article
- DOI
10.1038/sj.jhh.1001030