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- Title
A Prospective, Randomized, Controlled Study to Evaluate the Efficacy and Tolerability of Ayurvedic Formulation “Varuna and Banana Stem” in the Management of Urinary Stones.
- Authors
Patankar, Suresh; Dobhada, Satyen; Bhansali, Manish; Khaladkar, Suparn; Modi, Jayesh
- Abstract
Background: Medical management of urinary calculus disease is a challange for modern science. In the present trial Ayurvedic drug “Herbmed,” which is made up of varuna ( Crataeva nurvala) and banana stem ( Musa paradisiaca) was assessed to see reduction and/or expulsion of urinary calculi and also to assess the role of these drugs to reduce pain during expulsion. Materials and methods: In this prospective randomized, double-blind, placebo control trial, total 77 patients with calculi more than 5 mm were included. All patients were evaluated either by X-ray KUB or USG KUB for 3 months. All patients were divided into two groups: group A included patients with calculi 5–10 mm ( n = 31) and group B with calculi > 10 mm ( n = 30) with either active treatment or placebo in both the groups. All patients were asked to keep a record of number of pain episodes, while severity of pain was measured on a visual analogue scale (VAS). Results: In group A, there was 33.04% reduction in the size of calculi in the active arm while there was a 5.13% increase in the same group in the placebo arm ( p = 0.017). In the other group B, there was an 11.25% reduction in the active arm and a 1.41% reduction in the same group with placebo. In the active arm there was statistically significant lower VAS as compared to the placebo arm in the form of the highest VAS ( p = 0.008), average VAS ( p = 0.001) and VAS at the first episode of pain ( p < 0.0001). Conclusions: Our preliminary experience suggests that the Ayurvedic formulation “varuna and banana stem” has promise for the management of upper urinary-tract calculi, especially renal calculi. It helps to dissolve renal calculi and facilitate their passage. In addition, it also helps in reduction of pain due to renal/ureteric calculus disease. A larger phase III study with a longer follow-up is required.
- Subjects
AYURVEDIC medicine; URINARY organ diseases; ASIAN medicine; URINARY calculi; PLANTAIN banana; HERBAL medicine; MEDICAL care research; THERAPEUTICS
- Publication
Journal of Alternative & Complementary Medicine, 2008, Vol 14, Issue 10, p1287
- ISSN
1075-5535
- Publication type
Article
- DOI
10.1089/acm.2008.0189