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- Title
Dietary supplementation of red ginseng, Chinese lizard’s tail, and Korean raspberry extracts alleviate oxidative stresses in aged rats.
- Authors
Park, So-Min; Choi, Hae-Yeon; Lee, Eun-Ju; Park, Mi-Young; Lee, Jong-Won; Kim, Na-Mi; Sung, Mi-Kyung
- Abstract
To investigate antioxidant efficacy of medicinal plants known to possess anti-aging properties, the herb preparations were fed to 10-month-old rats. The herb preparations included ethanol extracts of red ginseng ( Panax ginseng C.A. Mayer), Chinese lizard’s tail ( Saururus chinensis Hort.ex Loud), and Korean raspberry (fruits of Rubus coreanus Miquel). Plasma protein carbonyls, malondialdehyde, 8-iso-prostaglandinF2α, lymphocyte DNA damage, α-tocopherol concentration, and ferric reducing ability were measured as oxidative stress markers. The aged rats showed higher levels of malondialdehyde, 8-isoprostaglandinF2α, and protein carbonyl and lower level of α-tocopherol compared to young rats. Malondialdehyde and protein carbonyl levels were decreased in the aged rats fed diets supplemented with any of the herbal preparations. 8-Iso-prostaglandinF2α was lower in rats fed the 0.5 or 1.0% Chinese lizard’s tail- or 1% Korean raspberry extract-supplemented diet. The 1:1:1 mixture of herbal preparations decreased the level of 8-iso-prostaglandinF2α. Rats fed 1.0% Chinese lizard’s tail or Korean raspberry diets showed increased α-tocopherol level. These results indicated that the level of oxidative stress is increased in the aged animals and herbal preparations are effective in the alleviation of age-related oxidation.
- Publication
Food Science & Biotechnology, 2010, Vol 19, Issue 4, p967
- ISSN
1226-7708
- Publication type
Article
- DOI
10.1007/s10068-010-0135-6