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- Title
Human Cancer Long Non-Coding RNA Transcriptomes.
- Authors
Gibb, Ewan A.; Vucic, Emily A.; Enfield, Katey S. S.; Stewart, Greg L.; Lonergan, Kim M.; Kennett, Jennifer Y.; Becker-Santos, Daiana D.; MacAulay, Calum E.; Lam, Stephen; Brown, Carolyn J.; Lam, Wan L.
- Abstract
Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome. LncRNAs are a novel class of mRNA-like transcripts which, despite no known protein-coding potential, demonstrate a wide range of structural and functional roles in cellular biology. However, the magnitude of the contribution of lncRNA expression to normal human tissues and cancers has not been investigated in a comprehensive manner. In this study, we compiled 272 human serial analysis of gene expression (SAGE) libraries to delineate lncRNA transcription patterns across a broad spectrum of normal human tissues and cancers. Using a novel lncRNA discovery pipeline we parsed over 24 million SAGE tags and report lncRNA expression profiles across a panel of 26 different normal human tissues and 19 human cancers. Our findings show extensive, tissue-specific lncRNA expression in normal tissues and highly aberrant lncRNA expression in human cancers. Here, we present a first generation atlas for lncRNA profiling in cancer.
- Subjects
RNA; CANCER; MESSENGER RNA; GENETIC regulation; GENE expression; TISSUES
- Publication
PLoS ONE, 2011, Vol 6, Issue 10, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0025915