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- Title
Task-Induced Deactivation from Rest Extends beyond the Default Mode Brain Network.
- Authors
Harrison, Ben J.; Pujol, Jesus; Contreras-Rodríguez, Oren; Soriano-Mas, Carles; López-Solà, Marina; Deus, Joan; Ortiz, Hector; Blanco-Hinojo, Laura; Alonso, Pino; Hernández-Ribas, Rosa; Cardoner, Narcís; Menchón, José M.
- Abstract
Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized 'default-mode network' (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes.
- Subjects
NEURAL circuitry; BRAIN imaging; CEREBRAL cortex; COGNITIVE analysis; PERFORMANCE; MAGNETIC resonance imaging
- Publication
PLoS ONE, 2011, Vol 6, Issue 7, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0022964