We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Clinical and Bacteriological Characteristics of IMP-Type Metallo β-Lactamase--Producing Pseudomonas aeruginosa.
- Authors
Hirakata, Yoichi; Yamaguchi, Toshiyuki; Nakano, Michiko; Izumikawa, Koichi; Mine, Mariko; Aoki, Shiho; Kondoh, Akira; Matsuda, Junichi; Hirayama, Mitsukuni; Yanagihara, Katsunori; Miyazaki, Yoshitsugu; Tomono, Kazunori; Yamada, Yasuaki; Kamihira, Shimeru; Kohno, Shigeru
- Abstract
IMP-type metallo-β-lactamase-producing bacteria have recently emerged worldwide. We conducted a case-control study in which 69 inpatients harboring bla[SUBIMP]-positive Pseudomonas aeruginosa and 247 control subjects with bla[SUBIMP]-negative pathogens were investigated. Prolonged hospitalization, antineoplastic chemotherapy, corticosteroid therapy (P = .001), and indwelling urinary catheters (P = .04) were risk factors for isolation of bla[SUBIMP]-positive pathogens. The predominant source was urine (P = .001). The duration of antibiotic treatment and the total dose (including of carbapenems) were significantly greater among case patients than among control subjects (P = .01). bla[SUBIMP]-positive P. aeruginosa isolates were more frequently resistant to multiple drugs (P = .001) and caused more infections (P = .001) than bla[SUBIMP]-negative pathogens. There were no significant differences in bacteriological outcome (P = .94); however, infection-related death was more frequent among case patients than among control subjects (P = .023). These results suggest that precautionary measures against the spread of bla[SUBIMP]-positive isolates are needed, because, for most of such pathogens, no antibiotic is potent enough to be used as a single agent in treatment of infection.
- Subjects
MICROBIAL enzymes; PSEUDOMONAS aeruginosa; ANTINEOPLASTIC agents; DIAGNOSTIC bacteriology
- Publication
Clinical Infectious Diseases, 2003, Vol 37, Issue 1, p26
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/375594