We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Entorhinal cortex astrocytic atrophy in human frontotemporal dementia.
- Authors
Rodríguez, J. J.; Zallo, F.; Gardenal, E.; Cabot, J.; Busquets, X.
- Abstract
The pathophysiology of Fronto Temporal Dementia (FTD) remains poorly understood, specifically the role of astroglia. Our aim was to explore the hypothesis of astrocytic alterations as a component for FTD pathophysiology. We performed an in-depth tri-dimensional (3-D) anatomical and morphometric study of glial fibrillary acidic protein (GFAP)-positive and glutamine synthetase (GS)-positive astrocytes in the human entorhinal cortex (EC) of FTD patients. The studies at this level in the different types of human dementia are scarce. We observed a prominent astrocyte atrophy of GFAP-positive astrocytes and co-expressing GFAP/GS astrocytes, characterised by a decrease in area and volume, whilst minor changes in GS-positive astrocytes in FTD compared to non-dementia controls (ND) samples. This study evidences the importance of astrocyte atrophy and dysfunction in human EC. We hypothesise that FTD is not only a neuropathological disease, but also a gliopathological disease having a major relevance in the understanding the astrocyte role in FTD pathological processes and development.
- Subjects
ENTORHINAL cortex; FRONTOTEMPORAL dementia; GLIAL fibrillary acidic protein; ATROPHY; GLUTAMINE synthetase
- Publication
Brain Structure & Function, 2024, Vol 229, Issue 3, p695
- ISSN
1863-2653
- Publication type
Article
- DOI
10.1007/s00429-024-02763-x