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- Title
Vitamin D Receptor 3' Haplotypes Are Unequally Expressed in Primary Human Bone Cells and Associated With Increased Fracture Risk: The MrOS Study in Sweden and Hong Kong.
- Authors
Grundberg, Elin; M. C.^ Lau, Edith; Pastinen, Tomi; Kindmark, Andreas; Nilsson, Olof; Ljunggren, Östen; Mellstrom, Dan; Orwoll, Eric; Redlund-Johnell, Inga; Holmberg, Anna; Gurd, Scott; Ping Chung Leung; Kwok, Timothy; Ohlsson, Claes; Mallmin, Hans; Brändstrom, Helena
- Abstract
The article presents the global Osteoporotic Fractures in Men (MrOS) study in Hong Kong and Sweden into the expression of vitamin D receptor 3 haplotypes, Hap1, Hap2, and Hap3 in human bone cells and fracture risk. Hap1 is linked with increased risk of vertebral fractures in Swedish men and with reduced lumbar spine bone mineral density in older men from both Hong Kong and Sweden.
- Subjects
VITAMIN D; BONE cells; BONE fractures; BONES; MINERALS in the body; RESEARCH; OSTEOPOROSIS
- Publication
Journal of Bone & Mineral Research, 2007, Vol 22, Issue 6, p832
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/JBMR.070317