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- Title
Restriction of Hepatitis C Virus Heterogeneity during Prolonged Interferon-a Therapy in Relation to Changes in Virus Load.
- Authors
Yun, Z. B.; Odeberg, J.; Lundeberg, J.; Weiland, O.; Uhlen, M.; Sönnerborg, A.
- Abstract
To determine how interferon-a (IFN-α) treatment changes the heterogeneity of the hepatitis C virus (HCV) population, the hypervariable region 1 (HVR1) was directly sequenced, and the virus load was quantified in 15 patients who had received IFN-α for 15 months. Before treatment, 13 patients exhibited heterogeneous HVR1 sequences. In 7 subjects who did not respond or did not sustain a response to treatment, significantly decreased heterogeneity of the HVR1 was found at the end of treatment (P = .01). In 6 of these patients, the virus load decreased in parallel with the changes in HVR1 heterogeneity. At follow-up, both the virus load and the heterogeneity increased in 4 patients, and the virus load, but not the heterogeneity, increased in 2. In the seventh patient, the virus load steadily increased during treatment and follow-up. These results suggest that a selection of HCV strains may occur during prolonged IFN-α treatment, concomitant with general suppression of the viral replication.
- Publication
Journal of Infectious Diseases, 1996, Vol 173, Issue 4, p992
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/173.4.992