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- Title
Infection with a Ratborne Hantavirus in US Residents Is Consistently Associated with Hypertensive Renal Disease.
- Authors
Glass, Gregory E.; Watson, Alan J.; LeDuc, James W.; Kelen, Gabor D.; Quinn, Thomas C.; Childs, James E.
- Abstract
A survey of 8080 subjects was conducted in Baltimore, examining the association between infection with hantaviruses and renal disease. Two groups (N = 6060) with no known risk factors were selected to establish a baseline antibody prevalence. Overall, antibody prevalence was 0.25%. Seroprevalence increased with age, without sex- or race-related differences. Patients with proteinuria showed the same patterns of infection but were more commonly seropositive (1.46%) than the reference group (OR, 3.23; P < .05). Infection among dialysis patients with end-stage renal disease was 2.76%, significantly higher than in the reference group (OR, 5.03; P < .05). In the proteinuria and the dialysis groups, hantavirus infection was consistently associated with a diagnosis of hypertensive renal disease. The association was unrelated to other chronic renal disease diagnoses. Overall, 6.5% of patients with end-stage renal disease due to hypertension were seropositive for a hantavirus. These data suggest that hantavirus infection is associated with hypertensive renal disease.
- Publication
Journal of Infectious Diseases, 1993, Vol 167, Issue 3, p614
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/167.3.614