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- Title
Cytomegalovirus Hepatitis in Liver Transplantation: Prospective Analysis of 93 Consecutive Orthotopic Liver Transplantations.
- Authors
Paya, Carlos V.; Hermans, Paul E.; Wiesner, Russell H.; Ludwig, Jurgen; Smith, Thomas F.; Rakela, Jorge; Krom, Ruud A. F.
- Abstract
Ninety-three consecutive orthotopic liver transplantations in 78 patients were followed prospectively to study the incidence of cytomegalovirus (CMV) hepatitis. CMV hepatitis occurred in 13 (170/0). The diagnosis was established by both histology and culture in 5, only by histology in 6, and only by culture in 2. All 13 patients had CMV viruria and 9 had viremia at diagnosis. CMV hepatitis developed in 640/0 of CMV-seronegative (pretransplantation) patients who received a liver from a CMV-seropositive donor, compared with 3% or 6% of CMV-seropositive patients who received a liver from a CMV-seronegative or CMV-seropositive donor, respectively (P <.(01). CMV hepatitis was not a cause of fulminant or irreversible liver dysfunction in any of the 13 cases. Ganciclovir was administered to 6 of the 13 patients and was associated with clinical and virologic cure in 5. CMV hepatitis was self-limited in patients not treated with ganciclovir (illness less severe). The presence of inclusions within the liver tissue correlated with active disease.
- Publication
Journal of Infectious Diseases, 1989, Vol 160, Issue 5, p752
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/160.5.752