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- Title
In situ immune response in human dermatophytosis: possible role of Langerhans cells (CD1a+) as a risk factor for dermatophyte infection.
- Authors
Ana Paula Carvalho Reis; Franciele Fernandes Correia; Thais Martins Jesus; Pagliari, Carla; Neusa Y. Sakai-Valente; Belda Júnior, Walter; Paulo Ricardo Criado; Benard, Gil; Maria Gloria Teixeira Sousa
- Abstract
Dermatophytosis is a cutaneous mycosis caused by a plethora of keratinophilic fungi, but Trichophyton rubrum is the most common etiological agent. Despite its high prevalence worldwide, little is known about the host defense mechanisms in this infection, particularly the in situ immune response. Using an immunohistochemistry approach, we investigated the density of CD1a+, factor XIIIa+ and CD68+ cells in the skin of dermatophytosis patients. Langerhans cells (CD1a+ cells) were significantly decreased in the epidermis of patients, both in affected and unaffected areas. In the dermis, however, no differences in the density of macrophages (CD68+ cells) and dermal dendrocytes (factor XIIIa+ cells) were observed. These results suggest that the decreased number of Langerhans cells may be a risk factor for development of dermatophytosis.
- Subjects
LANGERHANS cells; RINGWORM; IMMUNE response; PARACOCCIDIOIDOMYCOSIS; MYCOSES; INFECTION
- Publication
Revista do Instituto de Medicina Tropical de São Paulo, 2019, Vol 61, p1
- ISSN
0036-4665
- Publication type
Article
- DOI
10.1590/S1678-9946201961056