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- Title
Lyngbyastatins 8-10, Elastase Inhibitors with Cyclic Depsipeptide Scaffolds Isolated from the Marine Cyanobacterium Lyngbya semiplena.
- Authors
Kwan, Jason C.; Taori, Kanchan; Paul, Valerie J.; Luesch, Hendrik
- Abstract
Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8-10 (1-3). The structures of 1-3 were determined by NMR, MS, ESIMS fragmentation and chemical degradation. Compounds 1-3 are closely related to lyngbyastatins 4-7. Like the latter compounds, we found 1-3 to inhibit porcine pancreatic elastase, with IC50 values of 123 nM, 210 nM and 120 nM, respectively.
- Subjects
TUMON Bay (Guam); GUAM; LYNGBYA; STATINS (Cardiovascular agents); CYANOBACTERIA; LEUCOCYTE elastase; CYCLIC compounds; MARINE metabolites; ANTINEOPLASTIC agents; HYDROPHOBIC surfaces
- Publication
Marine Drugs, 2009, Vol 7, Issue 4, p528
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md7040528